Drug Resistance Mechanisms on Colorectal Cancer

Standard treatment for colorectal cancer includes surgery, radiotherapy, and chemotherapy. Conventional chemotherapeutic agents used in such as 5-fluorouracil, capecitabine which is oral form of irinotecan, oxaliplatin. One the major challenges chemotherapy considered drug resistance. Drug resistance occurs many different mechanisms alteration tumor microenvironment, growth kinetics, genetic variations, heterogeneity. These cytotoxic are combination to overcome on cancer. They can also be with bevacizumab cetuximab. Combination therapy depends burden, type, stage, molecular characteristics. It crucial choose applied by taking these factors into consideration. In this review, current were discussed then conventional related explained.